So, since no one has mentioned it yet, thought I'd pull out the signal light. I don't know much about this particular episode but...
In the newest reincarnation of the Powerpuff girls, there is or was an upcoming episode entitled: The Wrinklygruff Girls.
Here's what I know so far:
Due to an accident caused by Bubbles, the Pokey Oakes Kindergarten is closed. So, the girls venture into a new school where they are promptly made fun of because of how they look, and how they sound. Not wanting to appear immature in front of their new peers, the girls drink a potion to age them up, but it backfires on them, causing them to turn into the elderly.
I don't have much in regards of clips, but here's the preview in case you are interested:
https://www.youtube.com/watch?v=H4eZv2ZoCro