Some good points here. I have noticed that image sequences do tend to drag on for longer than they should, specially when dealing with narrative and dialog. I guess there is lots to think about.
There is a lot that's appealing about image sequences. In a practical sense, it's a lot easier to manage than the multi-panel page. Also, as I move towards a more 3D-heavy workflow, it's tempting to cross over into a format that more closely resembles animation.
For now I’ll be sticking with the traditional comic book format, though I may experiment with image sequences on a really short comic just to get a feel for it.
By the way, qzar9999, I'm a huge fan of Wolf Lake. It's some of the best written growth material I've seen.